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Normal temporal variability of the P100
Institution:1. School of Chemical Engineering, Shaanxi Key Laboratory of Degradable Medical Material, Northwest University, Xi''an 710069, Shaanxi, China;2. Department of Chemistry, Hong Kong Baptist University, Waterloo Road, Kowloon Tong, Hong Kong, China;3. Department of Chemistry and Biochemistry, The University of Texas at Austin, 1 University Station A5300, Austin, TX 78712-0165, United States;1. Division of Cardiovascular Medicine, Henry Ford Health System, Detroit, MI;2. Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI;3. Department of Medicine, Section of Cardiology, Veterans Affairs Medical Center, Ann Arbor, MI;4. Wayne State University, School of Medicine, Detroit, MI;1. Department of Health and Medical Sciences, Graduate School of Medicine, Shinshu University, Matsumoto, Japan;2. Department of Laboratory Medicine, Shinshu University Hospital, Matsumoto, Japan;3. Department of Laboratory Medicine, Graduate School of Medicine, Shinshu University, Matsumoto, Japan
Abstract:Determination of clinically significant temporal changes in P100 latency requires knowledge of the degree of normal intraindividual variability. Checkerboard visual evoked potentials using 3 check sizes (17′, 35′ and 70′) were performed serially on 20 healthy volunteers. Each subject was tested at least twice an average of 6 months apart. The P100 latency was measured at Oz with a forehead reference (Pz, O1 and O2 channels were also recorded). The overall average P100 latency change between studies for all check sizes and both eyes was 2.9 msec. However, the maximum absolute latency change was 11 msec. There was no significant difference between the average latency change for the 3 check sizes. The P100 interocular difference changed a mean of 2.5 msec (maximum 9 msec). Amplitude was more variable, with a mean change of about 1.5 μV or 25% (maximum was a 60% decrease in amplitude). A P100 latency change of up to at least 11 msec needs to be acknowledged as normal when assessing the clinical significance of changes in P100 latencies in patients. Also, P100 latency changes greater than 11 or 12 msec are very suggestive of an abnormality in the visual pathway.
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