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Developmental wave form analysis of the neonatal flash evoked potential
Institution:1. Institute of Epidemiology, Helmholtz Zentrum München, Germany;2. German Center for Diabetes Research (DZD), München-Neuherberg, Germany;3. Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Germany;4. Medical Faculty, Heinrich Heine University, Düsseldorf, Germany;5. Chair of Epidemiology, LMU Munich, UNIKA-T Augsburg, Germany;6. Former: Department of Hygiene, Social and Environmental Medicine, Ruhr-University Bochum, Germany;7. Molecular EXposomics, Helmholtz Zentrum München, Germany;8. Institute of Medical Epidemiology, Biostatistics, and Informatics, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany;9. Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Abstract:A multiple regression technique was used to describe the wave form of the flash evoked potential (VEP) in 64 neonates born between 28 and 39 weeks of gestation. The successive appearance of new features in the VEP with increasing gestational age at birth was used to define 5 components, of which specimens were obtained by averaging VEPs of 18 selected infants. The VEPs of the other 46 infants were expressed as linear sums of the components, each multiplied by a weighting coefficient. The method accounted for 74 ± 11% (mean ± 1 S.D.) of the rms power of the observed VEPs and was used to demonstrate significant effects on wave form maturation from fetal growth retardation and maternal smoking in pregnancy.
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