Clastogenic adaptation triggered by S-phase-independent clastogens in Vicia faba |
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| Affiliation: | 1. Zentralinstitut für Genetik und Kulturpflanzenforschung der Akademie de Wissenschaften der D.D.R., GDR-4325 Gatersleben G.D.R.;2. Department of Biology, Keio University, Yokohama 223 Japan;1. Senior Principal Scientist, Head of the DNA Damage Response Biology Area, Oncology IMED, AstraZeneca, Mereside, Alderley Park, Macclesfield SK10 4TG, United Kingdom;1. Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597;2. Department of Ecological and Biological Sciences, University of Tuscia, Viterbo 01100, Italy;3. Tembusu College, National University of Singapore, Singapore, 138597;1. College of Materials Science and Engineering, Xi''an University of Architecture and Technology, Xi''an, 710055, China;2. State Key Laboratory of Green Building in Western China, Xi''an University of Architecture and Technology, Xi''an, 710055, China;1. Clinical and Molecular Epidemiology, IRCCS San Raffaele Pisana, Rome, Italy;2. Department of Human Sciences and Quality of Life Promotion, San Raffaele University, Rome, Italy;3. Institute for Medical Research and Occupational Health, Mutagenesis Unit, Zagreb, Croatia |
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| Abstract: | Conditioning pretreatment of Vicia faba root-tip meristem cells with small doses of X-rays (0.06 Gy) or bleomycin, S-phase-independent clastogens, significantly reduced the yield of metaphases with chromatid aberrations induced by challenge doses of the same clastogens, administered 2 h after conditioning, i.e., resulted in clastogenic adaptation. Both clastogens were found to be able to substitute for each other in arousing protective effects (clastogenic cross-adaptation). |
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