Distribution and characterization of cyclo(His-Pro)-like immunoreactivity in the rat gastrointestinal tract |
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Authors: | M Mori J Pegues C Prasad R M Edwards J F Wilber |
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Affiliation: | Department of Medicine, Louisiana State University Medical Center, New Orleans, Louisiana 70112 USA |
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Abstract: | The distribution of cyclo(His-Pro), thyrotropin-releasing hormone (TRH) and activity was examined in the rat gastrointestinal (GI) tract. Cyclo(His-Pro)-like immunoreactivity was present in the following order of distribution (fmoles/mg protein): caecum > colon = jejunum = ileum > stomach = duodenum = rectum, and was immunologically and chromatographically identical with the authentic cyclo(His-Pro). Cyclo(His-Pro) concentrations showed significantly positive correlations with TRH concentrations, but not with activities, in most tissues of the GI tract, suggesting a precursor role of TRH for gut cyclo(His-Pro). These data suggest that cyclo(His-Pro) may be involved in regulating rat GI functions. |
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