枯草杆菌表达系统的研究进展

枯草杆菌由于具有非致病性、分泌蛋白能力强的特性的良好的发酵基础，是目前原核表达系统中分泌表达外源蛋白较理想的宿主。本阐述枯草杆菌基因表达的一般特点、表达载体、表达类型以及分泌表达存在的问题。

Progress in the expressing system of Bacillus subtilis

Bacillus subtilis is an attractive host for the production of heterologous secretory proteins for several reasons: it is non-pathogenic and capable of secreting functional extracellular proteins directly to the culture medium, a great deal of vital information concerning genetic manipulation and large-scale fermentation has now been acquired. This paper summarized the characteristics of gene expression, expressing vectors, the technology of the expression of heterologous protions and some limitations of secretory expression in Bacillus subtilis.