Molecular factors regulating E-cadherin expression in urothelial bladder cancer and their correlations with the clinicopathological features |
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| Authors: | Samia Hussein Hala Mosaad Hayam E. Rashed Shimaa Ahmed Ahmed Ragab Eman I. Ismail |
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| Affiliation: | 1.Medical Biochemistry and Molecular Biology Department, Faculty of Medicine,Zagazig University,Zagazig,Egypt;2.Pathology Department, Faculty of Medicine,Zagazig University,Zagazig,Egypt;3.Urology Department, Faculty of Medicine,Zagazig University,Zagazig,Egypt;4.Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine,Zagazig University,Zagazig,Egypt |
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| Abstract: | This study aimed to assess the expression of S100A4, Twist and E-cadherin (mRNA and protein) in urothelial bladder cancer, investigate the correlation between them and evaluate their association with the clinicopathological features of the disease. The study included 54 patients diagnosed as urothelial bladder cancer of different stages and grades. The expression levels of S100A4, Twist and E-cadherin (mRNA and protein) in tissue samples were determined by quantitative RT-PCR and immunohistochemistry. The expression of S100A4 and Twist was significantly upregulated while E- cadherin was significantly downregulated in urothelial bladder cancer tissues compared to the adjacent surrounding normal bladder tissues at both mRNA and protein levels (p?S100A4 and Twist expressions (r?=?0.875, p?E- cadherin and S100A4 expressions(r=- 0.803, p?E-cadherin and Twist (r?=??0.809, p?S100A4 and E- cadherin and between E- cadherin and Twist expression. However, there was a significant positive correlation between S100A4 and Twist expressions. Furthermore, the alterations in the gene expression were associated with disease stage and grade. |
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