(1) Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, 100191, P.R China;(2) Reproductive Medical Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, 100026, P.R China
Abstract:
Background
Tribbles 3 (TRB3) affects insulin signalling by inhibiting insulin-stimulated Akt phosphorylation and subsequent activation.
A single nucleotide polymorphism located in the second extron of the human TRB3 gene is thought to be associated with insulin
resistance. The latter is a core abnormality in PCOS independent of obesity. The present study was designed to clarify the
relationships of TRB3 Q84R polymorphism with PCOS in a Chinese women group.