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Association of TRB3 Q84R polymorphism with polycystic ovary syndrome in Chinese women |
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| Authors: | Xue Zhang Li Fu Qiufang Zhang Liying Yan Yanmin Ma Binbin Tu Nana Liu Jie Qiao |
| Institution: | (1) Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, 100191, P.R China;(2) Reproductive Medical Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, 100026, P.R China |
| Abstract: | BackgroundTribbles 3 (TRB3) affects insulin signalling by inhibiting insulin-stimulated Akt phosphorylation and subsequent activation. A single nucleotide polymorphism located in the second extron of the human TRB3 gene is thought to be associated with insulin resistance. The latter is a core abnormality in PCOS independent of obesity. The present study was designed to clarify the relationships of TRB3 Q84R polymorphism with PCOS in a Chinese women group. |
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