Biochemical and physiological characterization of the GTP-binding protein Obg of Mycobacterium tuberculosis |
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| Authors: | Smitha J Sasindran Sankaralingam Saikolappan Virginia L Scofield and Subramanian Dhandayuthapani |
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| Institution: | (1) Regional Academic Health Center and Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio, Edinburg, Texas 78541, USA |
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| Abstract: | Background Obg is a highly conserved GTP-binding protein that has homologues in bacteria, archaea and eukaryotes. In bacteria, Obg proteins
are essential for growth, and they participate in spore formation, stress adaptation, ribosome assembly and chromosomal partitioning.
This study was undertaken to investigate the biochemical and physiological characteristics of Obg in Mycobacterium tuberculosis, which causes tuberculosis in humans. |
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