Effect of nitrogen-rich cell culture surfaces on type X collagen expression by bovine growth plate chondrocytes |
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| Authors: | Alain Petit Caroline N Demers Pierre-Luc Girard-Lauriault Dorothy Stachura Michael R Wertheimer John Antoniou Fackson Mwale |
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| Institution: | 1.Lady Davis Institute for Medical Research,SMBD-Jewish General Hospital,Montreal,Canada;2.Division of Orthopaedic Surgery,McGill University Health Centre,Montreal,Canada;3.Department of Engineering Physics,école Polytechnique,Montréal,Canada |
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| Abstract: | Background Recent evidence indicates that osteoarthritis (OA) may be a systemic disease since mesenchymal stem cells (MSCs) from OA patients
express type X collagen, a marker of late stage chondrocyte hypertrophy (associated with endochondral ossification). We recently
showed that the expression of type X collagen was suppressed when MSCs from OA patients were cultured on nitrogen (N)-rich
plasma polymer layers, which we call "PPE:N" (N-doped plasma-polymerized ethylene, containing up to 36 atomic percentage (at.%)
of N. |
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