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Synthesis of sulfated derivatives of curdlan and their anti-HIV activity |
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| Authors: | Zenjiro Osawa Tsubura Morota Kenichi Hatanaka Toshihiro Akaike Kei Matsuzaki Hideki Nakashima Naoki Yamamoto Eiichiro Suzuki Hiroshi Miyano Tohru Mimura Yutaro Kaneko |
| Affiliation: | Faculty of Engineering, Gunma University, Kiryu, Gunma 376, Japan Department of Biomolecular Engineering, Tokyo Institute of Technology, Midoriku, Yokohama, Kanagawa 227, Japan Formerly, Faculty of Engineering, University of Tokyo, Bunkyoku, Tokyo 113, Japan Tokyo Medical and Dental University, Ochanomizu, Bunkyoku, Tokyo 113, Japan Ajinomoto Co., Inc., Kyobashi, Chuoku, Tokyo 108, Japan |
| Abstract: | Sulfopropyl curdlan was synthesized, its structure was determined, and the anti-HIV activity was compared with that of standard curdlan sulfates obtained with piperidine N-sulfonic acid in dimethyl sulfoxide. It was shown that sulfopropyl curdlan exhibits weaker anti-HIV activity than curdlan sulfate. Curdlan sulfates were synthesized with a SO3-pyridine complex in a heterogeneous phase. It was shown from 13C-NMR spectra of acetylated curdlan sulfates that they had a different substituent distribution from standard curdlan sulfate. The cytotoxicity of the curdlan sulfates was attributed to their heterogeneous structure. |
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