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X-ray induced sex-chromosome loss, when ring-X chromosome males are irradiated and mated to females carrying mei-9, mei-41 or mei-218 |
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| Authors: | C S Aaron B Leigh |
| Institution: | a Department of Biology, Faculty of Science, Kyushu University, Fukuoka 812, Japan b Radiation Biology Center, Kyoto University, Kyoto 606, Japan c Central Laboratory, Kanazawa Medical University, Ishikawa 920-02, Japan |
| Abstract: | DNA-repair characteristics of xeroderma pigmentosum belonging to complementation group F were investigated. The cells exhibited an intermediate level of repair as measured in terms of (1) disappearance of T4 endonuclease-V-susceptible sites from DNA, (2) formation of ultraviolet-induced strand breaks in DNA, and (3) ultraviolet-induced unscheduled DNA synthesis during post-irradiation incubation. The impaired ability of XP3YO to perform unscheduled DNA synthesis was restored, to half the normal level, by the concomitant treatment with T4 endonuclease V and ultraviolet-inactivated Sendai virus. It is suggested that xeroderma pigmentosum cells of group F may be defective, at least in part, in the incision step of excision repair. |
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