Conformationally restricted 3,4-diarylfuranones (2,3a,4,5-tetrahydronaphthofuranones) as selective cyclooxygenase-2 inhibitors |
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| Authors: | Pal Manojit Rao Veeramaneni Venugopal Nagabelli Murali Rao Kalleda Srinivas Misra Parimal Rao Casturi Seshagiri Rao Yeleswarapu Koteswar |
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| Affiliation: | Department of Chemistry, Discovery Research, Dr. Reddy's Laboratories Ltd., Bollaram Road, Miyapur, Hyderabad 500050, India. manojitpal@drreddys.com |
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| Abstract: | A number of naphthofuranones were synthesized and tested for COX-1 and COX-2 inhibition. Few of them were identified as selective COX-2 inhibitors. Structure-activity relationship studies within the series are discussed. |
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