Monocyte chemoattractant protein-1: a key mediator in inflammatory processes |
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Authors: | Melgarejo Esther Medina Miguel Angel Sánchez-Jiménez Francisca Urdiales José Luis |
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Affiliation: | Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Málaga, E-29071 Málaga, Spain. emelgarejo@uma.es |
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Abstract: | Monocyte chemoattractant protein-1 (MCP-1) is a potent chemoattractant for monocytes and macrophages to areas of inflammation. MCP-1 is a prototypical chemokine subject to coordinated regulation by immunomodulatory agents. Since MCP-1 is implicated in multiple inflammatory diseases, it is a potential target for the treatment of these disorders. In this review, we will provide background information and summarize the MCP-1 structure and signaling pathways. Its involvement in multiple diseases, such as tumour development, atherogenesis and rare autoimmune diseases is also revised. |
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