Characterization of conserved combined T and B cell epitopes in Leptospira interrogans major outer membrane proteins OmpL1 and LipL41 |
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| Authors: | Lin Xu'ai Sun Aihua Ruan Ping Zhang Zhe Yan Jie |
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| Institution: | (1) Department of Medical Microbiology and Parasitology, School of Medicine, Zhejiang University, 388 Yuhangtang Road, 310058 Hangzhou, PR China;(2) Basic Medical Microbiology Division, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, School of Medicine, Zhejiang University, 310058 Hangzhou, PR China;(3) Faculty of Basic Medicine, Zhejiang Medical College, 310053 Hangzhou, PR China;(4) Department of Medical Microbiology and Parasitology, Medical School of Shaoxing University, 312000 Shaoxing, PR China |
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| Abstract: | Background
Leptospira interrogans are bacterial pathogens of animal that cause zoonotic infections in human. Outer membrane proteins of leptospire are among
the most effective antigens which can stimulate remarkable immune responses during the infection processes, and thus are currently
considered leading candidate vaccine antigens. The objective of the present study is to predict and confirm major combined
B and T cell epitopes of leptospiral outer membrane proteins OmpL1 and LipL41, as well as to evaluate their capacity in the
induction of immune responses in BALB/c mice. |
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