Analysis on the reconstruction accuracy of the Fitch method for inferring ancestral states |
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| Authors: | Jialiang Yang Jun Li Liuhuan Dong Stefan Grünewald |
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| Institution: | (1) CAS-MPG Partner Institute for Computational Biology, Key Laboratory of Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 200031 Shanghai, PR China |
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| Abstract: | Background As one of the most widely used parsimony methods for ancestral reconstruction, the Fitch method minimizes the total number
of hypothetical substitutions along all branches of a tree to explain the evolution of a character. Due to the extensive usage
of this method, it has become a scientific endeavor in recent years to study the reconstruction accuracies of the Fitch method.
However, most studies are restricted to 2-state evolutionary models and a study for higher-state models is needed since DNA
sequences take the format of 4-state series and protein sequences even have 20 states. |
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