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High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease |
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| Authors: | Alan W Walker Jeremy D Sanderson Carol Churcher Gareth C Parkes Barry N Hudspith Neil Rayment Jonathan Brostoff Julian Parkhill Gordon Dougan Liljana Petrovska |
| Affiliation: | (1) Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA Hinxton, Cambridge, UK;(2) Biomedical & Health Sciences, Dept. of Nutrition and Dietetics, King’s College London, Franklin-Wilkins Building, 4th floor, 150 Stamford Street, SE1 8NH London, UK;(3) Department of Bacteriology, Veterinary Laboratories Agency (Weybridge), Woodham Lane, KT15 3NB Addlestone, Surrey, UK |
| Abstract: | BackgroundThe gut microbiota is thought to play a key role in the development of the inflammatory bowel diseases Crohn's disease (CD) and ulcerative colitis (UC). Shifts in the composition of resident bacteria have been postulated to drive the chronic inflammation seen in both diseases (the "dysbiosis" hypothesis). We therefore specifically sought to compare the mucosa-associated microbiota from both inflamed and non-inflamed sites of the colon in CD and UC patients to that from non-IBD controls and to detect disease-specific profiles. |
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