De novo complex chromosome rearrangement in identical twins with multiple congenital anomalies |
| |
| Authors: | Yoshiharu Wakita Kouji Narahara Kazushiro Tsuji Yuji Yokoyama Shinsuke Ninomiya Ryuko Murakami Kiyoshi Kikkawa Yoshiki Seino |
| |
| Institution: | (1) Department of Pediatrics, Okayama University Medical School, 2-5-1 Shikata-cho, 700 Okayama, Japan |
| |
| Abstract: | Summary A de novo and apparently balanced complex chromosome rearrangement (CCR) was found in monozygotic (MZ) twin infants with multiple congenital anomalies. The rearrangement involved 4 chromosomes with 6 breakpoints including 2p23, 2q13, 2q21.1, 3p23, 11q13.1, and 12q24.1. This seems to be the first report of a CCR in MZ twins. The relationship between this chromosome abnormality and MZ twinning is discussed. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
