Immunostimulating effect of triiodothyronine: dietary administration of triiodothyronine in rohu (Labeo rohita) enhances immunity and resistance to Aeromonas hydrophila infection |
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Authors: | P. K. Sahoo |
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Affiliation: | Central Institute of Freshwater Aquaculture, Kausalyaganga, Bhubaneswar, India |
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Abstract: | The immunomodulatory effects of dietary administration of 3,3′,5‐triiodo‐l ‐thyronine (T3) at 0, 1, 5 and 10 mg kg?1 of diet for 60 days in rohu (Labeo rohita) fingerlings were studied. Oral administration of T3 at all dose levels resulted in significantly (P<0.05) higher serum T3 levels, total serum protein and globulin levels, and reduced albumin–globulin ratio (A : G) compared with the control group, whereas feeding of T3 at 5 and 10 mg kg?1 diet enhanced the growth and superoxide production by neutrophils. At the end of the 60‐day experimental period the optimum dosage of T3 appeared to be the 5 mg kg?1 diet for rohu fingerlings, resulting in a significantly higher specific antibody titre against formalin‐killed Aeromonas hydrophila and lowering the mortality percentage against the A. hydrophila challenge. |
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