Effects of Undernutrition on Glutamatergic Parameters in Rat Brain |
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| Authors: | Rotta Liane N Schmidt André P e Souza Tadeu Mello Nogueira Cristina W Souza Karine B Izquierdo Ivan A Perry Marcos L S Souza Diogo O |
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| Institution: | (1) Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil;(2) Faculdade de Farmácia, Universidade Luterana do Brasil, Canoas, RS, Brazil;(3) Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil |
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| Abstract: | Early restriction of nutrients during the perinatal period has marked repercussions on CNS ontogeny, Leading to impaired functions. This study investigated the effects of pre- and postnatal (up to 75 days) undernutrition (diet: 8% protein; normonourished group: 25% protein) on some glutamatergic and behavioral parameters of rats. Undernutrition reduced: (i) seizures caused by ICV quinolinic acid (QA) administration; (ii) Na-independent 3H]glutamate binding in cell plasma membranes of cerebral cortex, and (ii) basal 3H]glutamate release from synaptosomal preparation. Behavioral parameters related to locomotion, anxiety, or memory were not affected. These results indicate that our model of undernutrition decreased the sensitivity to QA as convulsing agent and point to some putative glutamatergic parameters involved in this effect. |
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| Keywords: | Undernutrition glutamatergic system quinolinic acid seizures behavioral parameters |
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