Design and synthesis of highly potent and selective human peroxisome proliferator-activated receptor alpha agonists |
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| Authors: | Yamazaki Yukiyoshi Abe Kazutoyo Toma Tsutomu Nishikawa Masahiro Ozawa Hidefumi Okuda Ayumu Araki Takaaki Oda Soichi Inoue Keisuke Shibuya Kimiyuki Staels Bart Fruchart Jean-Charles |
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| Affiliation: | Tokyo New Drug Research Laboratories 1, Pharmaceutical Division, Kowa Co., LTD, 2-17-43, Noguchicho, Higashimurayam, Tokyo 189-0022, Japan. y-yamazk@kowa.co.jp |
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| Abstract: | A combination of benzoxazole, phenoxyalkyl side chain, and phenoxybutyric acids was identified as a highly potent and selective human peroxisome proliferator-activated receptor alpha (PPARalpha) agonist. The synthesis, structure-activity relationship (SAR) studies, and in vivo activities of the representative compounds are described. |
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