Interleukin-2-induced small unilamellar vesicle coalescence |
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| Authors: | Boni L T Batenjany M M Neville M E Guo Y Xu L Wu F Mason J T Robb R J Popescu M C |
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| Institution: | Biomira USA Inc., Cranbury, NJ 08512, USA. |
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| Abstract: | Recombinant human interleukin-2 (rhIL-2) was incorporated in liposomes for potential therapeutic applications using a novel process. In this process, rhIL-2 caused the formation of large, unique multilamellar vesicles (MLVs) from small unilamellar vesicles (SUVs) of dimyristoylphosphatidylcholine (DMPC). Vesicle coalescence occurred most rapidly at 19 degrees C, between the pre- and main phase transition temperatures of DMPC, and showed a dependence upon pH (pH <5.5), ionic strength (>50 mM) and the initial size of the unilamellar vesicles (
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