Escherichia coli K5 heparosan fermentation and improvement by genetic engineering |
| |
Authors: | Wang Zhenyu Dordick Jonathan S Linhardt Robert J |
| |
Affiliation: | Department of Biology, Center for Biotechnology & Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA. |
| |
Abstract: | N-acetyl heparosan is the precursor for the biosynthesis of the important anticoagulant drug heparin. The E. coli K5 capsular heparosan polysaccharide provides a promising precursor for in vitro chemoenzymatic production of bioengineered heparin. This article explores the improvements of heparosan production for bioengineered heparin by fermentation process engineering and genetic engineering. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|