Preparation of (S)-2,3-dichloro-1-propanol byPseudomonas sp. and its use in the synthesis of (R)-epichlorohydrin |
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Authors: | Naoya Kasai Kazuya Tsujimura Kinya Unoura Toshio Suzuki |
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Institution: | (1) Research and Laboratory of Daiso Co., Ltd., 9-Ootakasu cho, Amagasaki City Hyougo Pref. 660, Amagasaki City, Japan |
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Abstract: | Summary
Pseudomonas sp. OS-K-29 assimilated (R)-2,3-dichloro-1-propanol preferentially as the sole source of carbon. Isolation of optically pure (S)-2,3-dichloro-1-propanol with 100% enantiomer excess (e.e.) from the racemate was done based on this bacterial assimilation using immobilized-cells of OS-K-29 with calcium-alginate. The overall examination of the reactor involved 19 batches for 50 days without loss of its activity. Highly pure (R)-epichlorohydrin with 99.5% e.e. was prepared from the (S)-2,3-dichloro-1-propanol with treatment of aqueous NaOH. This new method is simple and useful for manufacturing optically active (S)-2,3-dichloro-1-propanol and (R)-epichlorohydrin. |
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Keywords: | Stereospecific degradation of 2 3-dichloro-1-propanol Pseudomonas sp Microbial resolution (S)-2 3-Dichloro-1-propanol |
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