Normal acute and chronic inflammatory responses in sphingosine kinase 1 knockout mice |
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Authors: | Michaud Jason Kohno Masataka Proia Richard L Hla Timothy |
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Affiliation: | Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030-3501, USA. |
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Abstract: | Sphingosine-1-phosophate, generated from the phosphorylation of sphingosine by sphingosine kinase enzymes, is suggested to function as an intracellular second messenger for inflammatory mediators, including formyl peptide, C5a, and Fc. More recently, a role for sphingosine kinases during inflammation has also been proposed. Here we show that sphingosine kinase 1 knockout mice exhibit normal inflammatory cell recruitment during thioglycollate-induced peritonitis and that sphingosine kinase 1-null neutrophils respond normally to formyl peptide. In the collagen-induced arthritis model of rheumatoid arthritis, sphingosine kinase 1 knockout mice developed arthritis with normal incidence and severity. Our findings show that sphingosine kinase 1 is dispensable for inflammatory responses and support the need for more extensive studies of sphingosine kinases in inflammation. |
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Keywords: | S1P, Sphingosine-1-phosophate Sphk1, Sphingosine kinase 1 Spp, Sphingosine-1-phosphate phosphatase SPL, Sphingosine-1-phosphate lyase CIA, Collagen-induced arthritis |
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