Molecular genetics and evolution of stomach and nonstomach lysozymes in the hoatzin |
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Authors: | Janet R Kornegay |
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Institution: | (1) Department of Molecular and Cell Biology, University of California, 401 Barker Hall, 94720-3202 Berkeley, CA, USA;(2) Present address: Roche Molecular Systems, 1145 Atlantic Ave., 94501 Alameda, CA, USA |
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Abstract: | Multiple genes of the hoatzin encoding stomach lysozyme c and closely related members of this calcium-binding lysozyme c group
were cloned from a genomic DNA library and sequenced. There are a minimum of five genes represented among these sequences
that encode two distinct groups of protein sequences. One group of three genes corresponds to the stomach lysozyme amino acid
sequences, and the remaining genes encode predicted proteins that are more basic in character and share several sequence identities
with the pigeon egg-white lysozyme rather than with the hoatzin stomach lysozymes. Despite these structural similarities between
some of the hoatzin gene products and the pigeon lysozyme, phylogenetic analyses indicate that all of the hoatzin sequences
are closely related to one another. This is borne out by the relatively small genetic distances even in the intronic regions,
which are not subject to the selective pressures operating on the coding regions of the stomach lysozymes. These results suggest
that multiple gene duplication events have occurred during the evolution of hoatzin lysozymes. |
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Keywords: | Hoatzin Stomach lysozyme Foregut fermentation Gene sequences Gene duplication Genetic variation Lysozyme evolution |
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