Tablet formulation studies on nimesulide and meloxicam-cyclodextrin binary systems |
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Authors: | Buchi N Nalluri K P R Chowdary K V R Murthy G Becket Peter A Crooks |
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Institution: | (1) Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam, India;(2) School of Pharmacy, University of Otago, Dunedin, New Zealand;(3) College of Pharmacy, University of Kentucky, Lexington, KY;(4) Faculty of Pharmaceutical Sciences, University of Kentucky, College of Pharmacy, 40536 Lexington, KY |
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Abstract: | The objective of this work was to develop tablet formulations of nimesulide-β-cyclodextrin (NI-β-CD) and meloxicam-γ-cyclodextrin
(ME-γ-CD) binary systems. In the case of nimesulide, 3 types of binary systems—physical mixtures, kneaded systems, and coevaporated
systems—were studied. In the case of meloxicam, 2 types of binary systems—physical mixtures and kneaded systems—were investigated.
Both drug-CD binary systems were prepared at 1∶1 and 1∶2 molar ratio (1∶1M and 1∶2M) and used in formulation studies. The
tablet formulations containing drug-CD binary systems prepared by the wet granulation and direct compression methods showed
superior dissolution properties when compared with the formulations of the corresponding pure drug formulations. Overall,
the dissolution properties of tablet formulations prepared by the direct compression method were superior to those of tablets
prepared by the wet granulation method. Selected tablet formulations showed good stability with regard to drug content, disintegration
time, hardness, and in vitro dissolution properties over 6 months at 40°C±2°C and 75% relative humidity.
Published: May 11, 2007 |
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Keywords: | Nimesulide meloxicam cyclodextrins tablet formulations dissolution properties stability studies |
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