(1) Division of Biological Effects, Bureau of Radiological Health, Food and Drug Administration, Department of Health, Education and Welfare, 5600 Fishers Lane, HFX-120, 20857 Rockville, Maryland
Abstract:
Summary The mutation frequency of L5178Y mouse lymphoma cells to resistance to 5′-bromo-2′-deoxyuridine increased 6-to 14-fold after
growth in ethylene oxide-sterilized polycarbonate culture flasks compared to growth in glass flasks. No comparable increase
was observed when L5178Y cells were growth in identical polycarbonate culture flasks sterilized by autoclaving.