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Mutagenic effect on L5178Y mouse lymphoma cells by growth in ethylene oxide-sterilized polycarbonate flasks |
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| Authors: | Kenneth Krell Elizabeth D Jacobson Katherine Selby |
| Institution: | (1) Division of Biological Effects, Bureau of Radiological Health, Food and Drug Administration, Department of Health, Education and Welfare, 5600 Fishers Lane, HFX-120, 20857 Rockville, Maryland |
| Abstract: | Summary The mutation frequency of L5178Y mouse lymphoma cells to resistance to 5′-bromo-2′-deoxyuridine increased 6-to 14-fold after growth in ethylene oxide-sterilized polycarbonate culture flasks compared to growth in glass flasks. No comparable increase was observed when L5178Y cells were growth in identical polycarbonate culture flasks sterilized by autoclaving. |
| Keywords: | ethylene oxide sterilization mutagenesis L5178Y cells plastic cell culture ware cell culture BUDR |
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