Deletion of UL21 causes a delay in the early stages of the herpes simplex virus 1 replication cycle |
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Authors: | Mbong Ekaette F Woodley Lucille Frost Elizabeth Baines Joel D Duffy Carol |
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Institution: | Department of Biological Sciences, University of Alabama, Tuscaloosa, Alabama, USA. |
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Abstract: | The herpes simplex virus 1 (HSV-1) U(L)21 gene encodes a 62-kDa tegument protein with homologs in the alpha-, beta-, and gammaherpesvirus subfamilies. In the present study, we characterized a novel U(L)21-null virus and its genetic repair to determine whether this protein plays a role in early stages of the HSV-1 replication cycle. Single-step growth analyses, protein synthesis time courses, and mRNA quantifications indicated that the absence of U(L)21 results in a delay early in the HSV-1 replication cycle. |
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