Effect of an exon 1 mutation in the myostatin gene on the growth traits of the Bian chicken |
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Authors: | Zhang G X Zhao X H Wang J Y Ding F X Zhang L |
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Institution: | College of Animal Science and Technology, Yangzhou University, China. |
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Abstract: | Myostatin (MSTN), or growth and differentiation factor 8 (GDF8), is a member of the transforming growth factor (TGF)-β superfamily. This family functions as a negative regulator of skeletal muscle development and growth in mammals. Single-nucleotide polymorphisms in exon 1 of the Bian chicken myostatin gene were detected by polymerase chain reaction-restriction fragment length polymorphism. A mutation (c.234G>A) in exon 1 was found. Female Bian chickens of genotypes AA and GA had significantly higher body weights than those of genotype GG (P < 0.05 or P < 0.01) from 6 to 18 weeks of age. These results suggested that the mutation c.234G>A in exon 1 could be used as a genetic marker for Bian chicken growth traits. |
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Keywords: | chicken growth traits myostatin gene PCR‐restriction fragment length polymorphism |
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