首页 | 本学科首页   官方微博 | 高级检索  
   检索      


The interleukin 4 receptor gene and its role in recurrent airway obstruction in Swiss Warmblood horses
Authors:Klukowska-Rötzler J  Swinburne J E  Drögemüller C  Dolf G  Janda J  Leeb T  Gerber V
Institution:Institute of Genetics, Vetsuisse Faculty, University of Bern, Switzerland. jolanta.klukowska@vetsuisse.unibe.ch
Abstract:Recurrent airway obstruction (RAO) in horses is the result of an interaction of genetic and environmental factors and shares many characteristics with human asthma. Many studies have suggested that the interleukin-4 receptor gene (IL4R) is associated with this disease, and a QTL region on chromosome 13 containing IL4R was previously detected in one of the two Swiss Warmblood families. We sequenced the entire IL4R gene in this family and detected 93 variants including five non-synonymous protein-coding variants. The allele distribution at these SNPs supported the previously detected QTL signal. Subsequently, we investigated IL4R mRNA expression in bronchoalveolar lavage fluid cells. During exacerbation, IL4R expression was increased in RAO-affected offspring in the implicated family, but not in the other family. These findings support that IL4R plays a role in some cases of RAO.
Keywords:association  expression  horse  interleukin 4 receptor  recurrent airway obstruction
本文献已被 PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号