Synthesis, SAR, and antitumor properties of diamino-C,N-diarylpyrimidine positional isomers: inhibitors of lysophosphatidic acid acyltransferase-beta |
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| Authors: | Gong Baoqing Hong Feng Kohm Cory Jenkins Scott Tulinsky John Bhatt Rama De Vries Peter Singer Jack W Klein Peter |
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| Affiliation: | Cell Therapeutics, Inc, 201 Elliott Ave W, Suite 400, Seattle, WA 98119, USA. |
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| Abstract: | 2,4-Diamino-N(4),6-diarylpyrimidines were identified as potent, isoform specific inhibitors of lysophosphatidic acid acyltransferase-beta (LPAAT-beta). Active inhibitors also blocked proliferation of tumor cell lines in vitro. The effect of 2j in an in vivo tumor model was investigated. |
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