Abnormal dorsal light response in teleost fish after intraocular injection of 6-hydroxydopamine |
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Authors: | C. A. McCormack M. T. McDonnell |
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Affiliation: | Department of Optometry and Vision Sciences, University of Wales College of Cardiff, PO Box 905, Cardiff CF1 3XF, U.K. |
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Abstract: | Following unilateral intraocular injection with 6-hydroxydopamine to the right eye, Midas cichlids displayed an acute abnormal dorsal light response, in favour of the right eye. This condition was reversed immediately by dopamine or dopamine receptor agonists delivered by intraocular injection but this recovery was not sustained, Retinal dopamine production reappeared gradually from day 30 post-6-hydroxydopamine treatment, and coincided with the fish beginning to adopt a normal dorsal light reaction. Dopamine production recovered completely at day 45 post-6-hydroxydopamine injection and coincided with complete recovery of the normal dorsal light reaction. These observations suggest a role for intraocular dopamine in maintenance of the visual part of the normal dorsal light reaction. |
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Keywords: | dorsal light response retinomotor movements circadian clocks 6-hydroxydopamine dopamine D1 and D2 receptor subtypes teleosts photoreceptors |
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