Inactivation of human cystatin C and kininogen by human cathepsin D |
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| Authors: | D Wilson-Shaw M Robinson C Gambarana R E Siegel J M Sikela |
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| Affiliation: | Department of Pharmacology, University of Colorado Health Sciences Center, Denver 80262. |
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| Abstract: | A papain inhibitor or 22 kDa was isolated from human placenta and shown to be identical to residues Cys246-Leu373 of the third domain of human kininogen. This kininogen domain and recombinant human cystatin C were inactivated by peptide bond cleavages at hydrophobic amino acid residues due to the action of cathepsin D. These results further support the proposed role cathepsin D in the regulation of cysteine proteinase activity. |
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| Keywords: | Cystatin C Kininogen, Cathepsin D Proteinase inhibitor inactivation |
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