New opportunities in integrative structural modeling |
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Affiliation: | 1. European Molecular Biology Laboratory Hamburg, Notkestraße 85, 22607, Hamburg, Germany;2. Centre for Structural Systems Biology (CSSB), Notkestraße 85, 22607, Hamburg, Germany;3. Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstraße 1, 69117, Heidelberg, Germany |
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Abstract: | Integrative structural modeling enables structure determination of macromolecules and their complexes by integrating data from multiple sources. It has been successfully used to characterize macromolecular structures when a single structural biology technique was insufficient. Recent developments in cellular structural biology, including in-cell cryo-electron tomography and artificial intelligence-based structure prediction, have created new opportunities for integrative structural modeling. Here, we will review these opportunities along with the latest developments in integrative modeling methods and their applications. We also highlight open challenges and directions for further development. |
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