Alternative pathways driven by STING: From innate immunity to lipid metabolism |
| |
| Affiliation: | 1. Institut de Génétique Humaine, Univ Montpellier, CNRS, Montpellier, France;2. Aarhus University, Department of Biomedicine, Aarhus, Denmark;1. NanoBioCel Research Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country (UPV/EHU), Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, Spain;2. Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Institute of Health Carlos III, 28029 Madrid, Spain;3. Bioaraba, NanoBioCel Research Group, 01006 Vitoria-Gasteiz, Spain;1. Centre of Reproduction, Development and Aging and Institute of Translation Medicine, Faculty of Health Sciences, University of Macau, Macau 999078, China;2. Brain Research Centre and Department of Biology, School of Life Science, Southern University of Science and Technology, 1088 Xueyuan Blvd, Nanshan District, Shenzhen, Guangdong Province 518055, China;3. Allergy and Clinical Immunology Unit, Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem 9112001, Israel;4. Anesthesia, Critical Care Medicine and Physiology, St. Michael’s Hospital, University of Toronto, Ontario, Canada;5. Institute for Global Food Security, School of Biological Sciences, Queen''s University Belfast, Belfast BT9 5DL, United Kingdom;6. Pharmacology, School of Pharmacy Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112002, Israel;1. Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093-0367, USA;2. UCSD Moores Cancer Center, University of California San Diego, La Jolla, CA 92093-0367, USA;1. Department of Gastroenterology and Hepatology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Digestive Disease, State Key Laboratory for Oncogenes and Related Genes, NHC Key Laboratory of Digestive Diseases, Shanghai 200001, China;2. Department of Gastroenterology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing University, Nanjing 210093, China;1. Department of Biochemistry, Stanford School of Medicine, Stanford University, Stanford, CA 94305, USA;2. Macromolecular Structure Knowledge Center (MSKC), Stanford University, Stanford, CA 94305, USA;3. Stanford ChEM-H, Stanford University, Stanford, CA 94305, USA;4. SLAC National Accelerator Laboratories, Menlo Park, CA 94025, USA |
| |
| Abstract: | The Stimulator of Interferon Genes (STING) is a major adaptor protein that is central to the initiation of type I interferon responses and proinflammatory signalling. STING-dependent signalling is triggered by the presence of cytosolic nucleic acids that are generated following pathogen infection or cellular stress. Beyond this central role in controlling immune responses through the production of cytokines and chemokines, recent reports have uncovered inflammation-independent STING functions. Amongst these, a rapidly growing body of evidence demonstrates a key role of STING in controlling metabolic pathways at several levels. Since immunity and metabolic homeostasis are tightly interconnected, these findings deepen our understanding of the involvement of STING in human pathologies. Here, we discuss these findings and reflect on their impact on our current understanding of how nucleic acid immunity controls homeostasis and promotes pathological outcomes. |
| |
| Keywords: | STING Inflammation Innate immunity Lipid metabolism Metabolism |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
