Nucleic acid actions on abnormal protein aggregation,phase transitions and phase separation |
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Affiliation: | 1. Faculty of Pharmacy, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil;2. Instituto de Bioquímica Médica Leopoldo de Meis, Instituto Nacional de Ciência Tecnologia de Biologia Estrutural e Bioimagem, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil;3. Department of Cell and Molecular Biology, Uppsala University, Uppsala, Box-596, 75124, Sweden |
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Abstract: | Liquid–liquid phase separation (LLPS) and phase transitions (PT) of proteins, which include the formation of gel- and solid-like species, have been characterized as physical processes related to the pathology of conformational diseases. Nucleic acid (NA)-binding proteins related to neurodegenerative disorders and cancer were shown by us and others to experience PT modulated by different NAs. Herein, we discuss recent work on phase separation and phase transitions of two amyloidogenic proteins, i.e. the prion protein (PrP) and p53, which undergo conformational changes and aggregate upon NA interaction. The role of different NAs in these processes is discussed to shed light on the relevance of PSs and PTs for both the functional and pathological roles of these mammalian proteins. |
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Keywords: | IDP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0040" }," $$" :[{" #name" :" text" ," _" :" intrinsically disordered protein LLPS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0050" }," $$" :[{" #name" :" text" ," _" :" liquid-liquid phase separation NA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0060" }," $$" :[{" #name" :" text" ," _" :" nucleic acid p53C" },{" #name" :" keyword" ," $" :{" id" :" kwrd0070" }," $$" :[{" #name" :" text" ," _" :" p53 core domain PLD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0080" }," $$" :[{" #name" :" text" ," _" :" prion-like domain PLP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0090" }," $$" :[{" #name" :" text" ," _" :" prion-like protein PrP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0100" }," $$" :[{" #name" :" text" ," _" :" prion protein rPrP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0110a" }," $$" :[{" #name" :" text" ," _" :" recombinantprion protein PS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0110b" }," $$" :[{" #name" :" text" ," _" :" phase separation PT" },{" #name" :" keyword" ," $" :{" id" :" kwrd0110c" }," $$" :[{" #name" :" text" ," _" :" phase transition RE" },{" #name" :" keyword" ," $" :{" id" :" kwrd0110d" }," $$" :[{" #name" :" text" ," _" :" responsive element TSE" },{" #name" :" keyword" ," $" :{" id" :" kwrd0110f" }," $$" :[{" #name" :" text" ," _" :" transmissible spongiform encephalopathy GoF" },{" #name" :" keyword" ," $" :{" id" :" kwrd0110g" }," $$" :[{" #name" :" text" ," _" :" gain-of-function |
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