An emerging mechanism for the maturation of the Small Subunit Processome |
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| Institution: | 1. Wellcome Trust Centre for Cell Biology, University of Edinburgh, Michael Swann Building, Kings Buildings, Mayfield Road, Edinburgh EH9 3JR, Scotland;2. Department of Molecular Biosciences, WGI, Stockholm University, 106 91 Stockholm, Sweden;3. Department of Microbiology, Immunology and Cancer Biology, University of Virginia Health System, Charlottesville, VA 22908-0734, USA;4. SynthSys, JR Waddington Building, Kings Buildings, Mayfield Road, Edinburgh EH9 3JR, Scotland;1. Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;2. Laboratory of Protein and Nucleic Acid Chemistry, The Rockefeller University, New York, NY 10065, USA;3. Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;4. Cryo-Electron Microscopy Facility, Janelia Research Campus, Ashburn, VA 20147, USA;5. Molecular Cytology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;6. Laboratory of Cell Biology and Genetics, The Rockefeller University, New York, NY 10065, USA;7. Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA;8. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA;1. Max Planck Institute for Terrestrial Microbiology, Karl-von-Frisch Straße 10, 35043 Marburg, Germany;2. Department of Chemistry, University of Marburg, Hans-Meerwein-Straße 4, 35032 Marburg, Germany;3. Center for Synthetic Microbiology (SYNMIKRO), Hans-Meerwein-Straße 6, 35032 Marburg, Germany;1. Department of Biological Science, Institute of Molecular Biophysics, Florida State University, 91 Chieftain Way, Tallahassee, FL 32306, USA;2. Department of Cancer Biology, The Scripps Research Institute, Jupiter, FL 33458, USA |
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| Abstract: | The biogenesis of the eukaryotic ribosome is a tightly regulated and energetically demanding process involving more than 200 ribosome assembly factors. These factors work in concert to ensure accurate assembly and maturation of both ribosomal subunits. Cryo-electron microscopy (cryo-EM) structures of numerous eukaryotic ribosome assembly intermediates have provided a wealth of structural insights highlighting the molecular interplay of a cast of assembly factors. In this review, we focus on recently determined structures of maturing small subunit (SSU) processomes, giant precursors of the small ribosomal subunit. Based on these structures and complementary biochemical and genetic studies, we discuss an emerging mechanism involving exosome-mediated SSU processome maturation and disassembly. |
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