Mechanistic insights into fungal mitochondrial outer membrane protein biogenesis |
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| Affiliation: | 1. Cardiology Department, Cardiovascular Institute (ICCV), Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain.;2. Interventional Cardiology Section, Cardiology Service, University Hospital of Badajoz, Avda Elvas sn Badajoz, 06080 Badajoz, Spain.;3. Department of Cardiology, Hospital Universitario de Salamanca, IBSAL, Paseo de San Vicente, 58, Salamanca 37007, Spain.;4. Cardiovascular Institute, Hospital Clínico San Carlos, IdISSC, Madrid, Spain.;5. Department of Cardiology, University Hospital of León, León, Spain;6. Centro de Investigación Biomédica en Red Enfermedades Cardiovaculares (CIBERCV), Spain |
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| Abstract: | The majority of mitochondrial proteins are nuclear-encoded and need to be transported into the mitochondria, including the proteins in the outer mitochondrial membrane. For β-barrel proteins, the preproteins are initially recognized and imported by the TOM complex, then shuttled to the SAM complex via small Tim proteins. For ⍺-helical proteins, some preproteins are recognized by the TOM complex and imported into the membrane by the MIM complex. In recent years multiple structures of the TOM complex and the SAM complex have been reported, increasing our understanding of the mechanism of protein biogenesis in the outer mitochondrial membrane. |
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