Crosstalk between lncRNAs in the apoptotic pathway and therapeutic targets in cancer |
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| Affiliation: | 1. Genetics Division, Department of Cell and Molecular Biology and Microbiology, Faculty of Science and Technology, University of Isfahan, Iran;2. Research Institute for Oncology, Hematology and Cell Therapy, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran;3. Department of Cellular and molecular, School of Biological Sciences, Islamic Azad University of Falavarjan, Iran;4. Biotechnology department of Fasa University of medical science, Fasa, Iran;5. Department of Biology, Faculty of Science, University Of Isfahan, Isfahan, Iran;6. Monoclonal Antibody Research Center, Avicenna Research Institute, ACECR, Tehran, Iran;7. Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran;8. Department of Genetics, Faculty of Basic Sciences, Shahrekord University, Iran;9. Department of Biological Science and Technology, Faculty of Nano and Bio Science and Technology, Persian Gulf University, Bushehr 75169, Iran;10. Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA;1. College of Medicine, University of Sharjah, Sharjah 27272, UAE;2. Blood and Vascular Biology Research Lab, Department of Life Sciences, Central University of Tamil Nadu, Thiruvarur 610005, India;3. Dermatology Institute, Translational Research Institute, Academic Health Systems, Hamad Medical Corporation, PO Box 3050, Doha, Qatar;4. Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, UAE;1. Department of Physiological Sciences, University of Stellenbosch, Stellenbosch, South Africa;2. Department of Internal Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg Campus, South Africa;3. African Cancer Institute (ACI), Department of Global Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa;4. Cancer Care SA, Cape Gate and Panorama Oncology Centres, Cape Town, South Africa;1. Department of Immunology, Jiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, China;2. Department of Laboratory Medicine, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, China;3. Department of Laboratory Medicine, The Affiliated People’s Hospital, Jiangsu University, Zhenjiang, China;1. Health Sciences Institute, Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases, China Medical University, Shenyang 110122, Liaoning, China;2. College of Basic Medical Science, Key Laboratory of Medical Cell Biology, Ministry of Education, Key Laboratory of Liaoning Province, China Medical University, Shenyang 110122, Liaoning, China;3. Innovation Institute, China Medical University, China Medical University, Shenyang 110122, Liaoning, China;4. Department of Clinical Nutrition, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning, China;1. Department of Anatomy and Histology, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur 1706, Bangladesh;2. Bio-ID Centre, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China |
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| Abstract: | The assertion that a significant portion of the mammalian genome has not been translated and that non-coding RNA accounts for over half of polyadenylate RNA have received much attention. In recent years, increasing evidence proposes non-coding RNAs (ncRNAs) as new regulators of various cellular processes, including cancer progression and nerve damage. Apoptosis is a type of programmed cell death critical for homeostasis and tissue development. Cancer cells often have inhibited apoptotic pathways. It has recently been demonstrated that up/down-regulation of various lncRNAs in certain types of tumors shapes cancer cells' response to apoptotic stimuli. This review discusses the most recent studies on lncRNAs and apoptosis in healthy and cancer cells. In addition, the role of lncRNAs as novel targets for cancer therapy is reviewed here. Finally, since it has been shown that lncRNA expression is associated with specific types of cancer, the potential for using lncRNAs as biomarkers is also discussed. |
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| Keywords: | LncRNAs Apoptosis Cancer therapy Biomarkers Therapeutic target |
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