PLR、NLR、CRP与老年AECOPD患者病情严重程度、近期预后的关系

摘要 目的：探讨血小板/淋巴细胞比值（PLR）、中性粒细胞/淋巴细胞比值（NLR）、C反应蛋白（CRP）与老年慢性阻塞性肺疾病急性加重期（AECOPD）患者病情严重程度、近期预后的关系。方法：选取97例老年AECOPD患者为疾病组，另取同期31例体检健康者为对照组。测定两组受试者PLR、NLR、CRP水平，比较不同病情严重程度患者PLR、NLR、CRP水平，并分析PLR、NLR、CRP与患者近期预后的关系以及三者联合评估患者预后的价值。结果：疾病组PLR、NLR、CRP水平高于对照组（P<0.05）；随着病情严重程度加重，PLR、NLR、CRP水平依次升高（P<0.05）；预后不良组PLR、NLR、CRP水平高于预后良好组（P<0.05）；ROC曲线结果显示，PLR、NLR、CRP联合评估患者预后的AUC为0.943，高于单项评估（P<0.05）。结论：PLR、NLR、CRP水平变化均可以反映老年AECOPD患者病情严重程度，且可以用来评估预后，联合评估其价值更高。

Relationship between PLR, NLR, CRP and Disease Severity, Short-term Prognosis in Elderly Patients with AECOPD

ABSTRACT Objective: To explore the relationship between platelet/lymphocyte ratio (PLR), neutrophil/lymphocyte ratio (NLR), C-reactive protein (CRP) and disease severity, short-term prognosis in elderly patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods: A total of 97 elderly patients with AECOPD and 31 healthy controls were enrolled as disease group and control group, respectively. PLR, NLR and CRP in the two groups were detected, and which were compared among patients with different disease severity. The relationship between PLR, NLR, CRP and short-term prognosis, and their evaluation value for prognosis were analyzed. Results: PLR, NLR and CRP in disease group were higher than those in control group (P<0.05). With the aggravation of the disease, PLR, NLR and CRP were increased (P<0.05). PLR, NLR and CRP in poor prognosis group were higher than those in good prognosis group (P<0.05). The results of ROC curves showed that AUC of PLR combined with NLR and CRP for evaluating prognosis was 0.943, greater than that of single index (P<0.05). Conclusion: The changes of PLR, NLR and CRP can reflect disease severity in elderly patients with AECOPD. PLR, NLR and CRP can be applied to evaluate prognosis, and their combined detection has higher value.