Translational control during mitosis |
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Authors: | Le Breton Magali Cormier Patrick Bellé Robert Mulner-Lorillon Odile Morales Julia |
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Affiliation: | Equipe Cycle Cellulaire et Développement, UMR 7150 CNRS/UPMC, Station Biologique de Roscoff, BP 74, 29682 Roscoff cedex, France. |
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Abstract: | Translation is now recognized as an important process in the regulation of gene expression. During the cell cycle, translation is tightly regulated. Protein synthesis is necessary for entry into and progression through mitosis and conversely, modifications of translational activity are observed during the cell cycle. This review focuses on translational control during mitosis (or M-phase) and the role of CDK1/cyclin B, the universal cell cycle regulator implicated in the G2/M transition, in protein synthesis regulation. |
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