Differential response of Vibrio cholerae planktonic and biofilm cells to autoinducer 2 deficiency |
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Authors: | Syed A Ali Jorge A Benitez |
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Institution: | Morehouse School of Medicine Department of Microbiology, Biochemistry and Immunology, 720 Westview Drive, SW Atlanta, Georgia 30310, USA |
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Abstract: | The formation of biofilm communities enhances the persistence of Vibrio cholerae in aquatic environments. Biofilm production is repressed by the quorum-sensing regulator HapR in response to the accumulation of CAI-1 and AI-2. CAI-1 is the strongest input signal activating HapR, whereas the role of AI-2 remains ill-defined. In the present study, we show that a V. cholerae luxS (AI-2-defective) mutant made increased biofilm. Interestingly, cells in the biofilm were more responsive to AI-2 deficiency than cells from the planktonic population. |
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Keywords: | autoinducer 2 biofilm quorum sensing Vibrio cholerae |
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