Effects on intestinal nutrient uptake and brush border membrane enzymes in response to atherogenic diet in rhesus monkeys |
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Authors: | G S Dhaunsi G S Sidhu U C Garg Y Singh R N Chakravarti R Bhatnagar |
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Institution: | Department of Experimental Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India. |
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Abstract: | Transport of nutrients and kinetic parameters (Vmax and Km) of brush border membrane (BBM) enzymes were studied in duodenum, jejunum, and ileum from atherogenic diet-fed monkeys. The Km remained unaltered while feeding of atherogenic diet resulted in higher Vmax of sucrase, maltase, and alkaline phosphatase and lower Vmax of gamma-glutamyltranspeptidase and leucine-aminopeptidase compared to controls. Na+-dependent D-glucose transport was higher in duodenum and jejunum and unaltered in ileum. In contrast to D-glucose transport, the transport of amino acids was decreased in all three intestinal segments from atherogenic diet-fed monkeys. |
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Keywords: | Brush border membrane Nutrient transport Cholesterol |
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