Mitoxantrone toxicity on Ehrlich ascites tumour cells: inhibition of the transplasma membrane redox activity |
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Authors: | Miguel Angel Medina,Pilar Luque,Ignacio NÚ ez De Castro |
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Affiliation: | Laboratorio de Bioquimica, Facultad de Ciencias, Universidad de Málaga, Spain. |
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Abstract: | This study focused on the potent cytotoxic effect that mitoxantrone produces on Ehrlich ascites tumour cells. Host mice treated with mitoxantrone showed a life span three times higher than control non-treated host mice. Mitoxantrone also showed a potent cytotoxic effect on Ehrlich cells incubated in vitro for only a few hours. Studies on the effect of mitoxantrone on a plasma membrane redox system showed that mitoxantrone inhibits this activity, which is apparently related to cell proliferation. |
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Keywords: | Mitoxantrone ferricyanide reductase Ehrlich cells |
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