Considerations into the mechanism of estrogen-stimulated uterine prostaglandin synthesis |
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Authors: | VDaniel Castracane VCraig Jordan |
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Institution: | Worcester Foundation for Experimental Biology Shrewsbury, Massachusetts 01545 USA |
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Abstract: | Progesterone priming of the ovariectomized rat, followed by a single injection of estradiol-17β (10 μg) is followed by an increased uterine synthesis of both PGF and PGE. The administration of an estrogen antagonist (MER-25; 10 mg) concomitantly with estradiol had no effect on uterine prostaglandin synthesis. Similarly, the administration of either Actinomycin D or cycloheximide, antibiotics demonstrated to inhibit mRNA and protein synthesis, respectively, is without effect on estrogen-stimulated uterine prostaglandin synthesis. These results are considered with regard to the classic receptor theory of estrogen action and are a preliminary indication that estrogen-stimulated uterine prostaglandin synthesis may not require those receptor mediated events. |
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