S-100 protein in Schwann cells of the developing human peripheral nerve |
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Authors: | Jeremy D. Shearman Antony J. Franks |
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Affiliation: | (1) Neuropathology Laboratory, Department of Pathology, University of Leeds, Leeds, UK;(2) Neuropathology Laboratory, Department of Pathology, University of Leeds, LS2 9JT Leeds, UK |
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Abstract: | Summary From approximately 7 weeks gestational age in developing human peripheral nerve, as in adult nerve, S-100 protein was found to be expressed solely and uniformly by Schwann cells associated with axons. In embryos younger than 7 weeks S-100 was much less constant and many cells did not show clear staining. The trigger for the initial appearance of the protein at around this age remains unclear although a relationship of S-100 expression in Schwann cells to close axonal contact is suggested. The value of S-100 protein in distinguishing Schwann cells from perineurial cells in normal nerves and nerve sheath tumours remains unclear. |
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Keywords: | S-100 protein Immunohistochemistry Schwann cells Neurilemoma Human foetus |
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