Department of Chemistry, University of York, U.K.;Hoechst Pharmaceutical Research Laboratories, Walton, Milton Keynes, U.K.
Abstract:
Kinetic studies on cis-Pt(NH3)2(OH2)2]2+ and various nucleobases show that this ion reacts more quickly with guanosine than with adenosine, cytidine, and thymidine, and that a monophosphoric acid unit considerably enhances the rate of reaction of guanosine; the kinetic preference of 5'-GMP over 5'-AMP may point to a greater thermodynamic selectivity.