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Kinetic studies on the diaqua form of cis-platin and various nucleobases |
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| Authors: | S Eapen M Green I M Ismail |
| Institution: | Department of Chemistry, University of York, U.K.;Hoechst Pharmaceutical Research Laboratories, Walton, Milton Keynes, U.K. |
| Abstract: | Kinetic studies on cis-Pt(NH3)2(OH2)2]2+ and various nucleobases show that this ion reacts more quickly with guanosine than with adenosine, cytidine, and thymidine, and that a monophosphoric acid unit considerably enhances the rate of reaction of guanosine; the kinetic preference of 5'-GMP over 5'-AMP may point to a greater thermodynamic selectivity. |
| Keywords: | A adenosine G guanosine C cytidine T thymidine Address reprint requests to Dr M Green Department of Chemistry University of York Heslington York Y01 5DD U K |
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