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Improved synthesis of dicyclohexylidene protected quebrachitol and its use in the synthesis of L-chiro-inositol derivatives |
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| Authors: | Baars Sylvia M Hoberg John O |
| Affiliation: | School of Chemical and Physical Sciences, Victoria University of Wellington, Wellington, New Zealand. |
| Abstract: | A modified synthesis of 1L-1,2:3,4-di-O-cyclohexylidene-5-O-methyl-chiro-inositol has been accomplished that improves the overall procedure, yield, and environmental aspects of its formation. Several inositol analogues have been prepared from this intermediate for testing as biosynthetic inhibitors of glycosyl-phosphatidylinositol (GPI) anchor formation. |
| Keywords: | Inositol protection Quebrachitol 1 smallcaps" >l-1,2:3,4-Di-O-cyclohexylidene-5-O-methyl-chiro-inositol chiro-Inositol derivatives |
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