From ER to Eph receptors: new roles for VAP fragments |
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Authors: | Ackerman Susan L Cox Gregory A |
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Affiliation: | The Jackson Laboratory, Bar Harbor, ME 04609, USA. susan.ackerman@jax.org |
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Abstract: | Dominantly inherited mutations in an endoplasmic reticulum protein called VAPB have been found in a subset of patients with a rare familial form of amyotrophic lateral sclerosis (ALS). In this issue, Tsuda et al. (2008) identify a secreted form of VAPB that binds directly to Eph receptors inducing their activation and signaling, providing fresh insights into ALS pathogenesis, including non-neuronal aspects of this disorder. |
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