Identification and characterization of the cAMP binding proteins of yeast by photoaffinity labeling. |
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Authors: | C Dery S Cooper M A Savageau S Scanlon |
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Affiliation: | 1. Department of Pediatrics, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA;2. Children''s Hospital of Philadelphia, Philadelphia, PA 19104 USA |
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Abstract: | Modulation of a membrane glycoprotein, approximate molecular weight 200,000, in concert with active ionic flux has been shown in a human neuroblastoma cell line. The modulating agent was 2% dimethyl sulfoxide. Other neuronal properties, acetylcholinesterase and choline acetyltransferase, were also modulated but to a lesser extent. The appearance of this glycoprotein on the surface of both human and mouse neuroblastoma cells only under conditions of differentiation leads to the suggestion that it is directly involved with the active Na+ channels. |
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